CASE REPORT: Hyper-Immunoglobulin E Syndrome and Squamous Cell Carcinoma of the Lower Lip: A Case Report

West Afr J Med. 2021 Feb;38(2):180-184. PMID: 33641156

Authors

  • A. O. Akinboro Department of Internal Medicine, Ladoke Akintola University of Technology, Ogbomoso and LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
  • M. O. Onigbinde Department of Paediatrics, Ladoke Akintola University of Technology, Ogbomoso and LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
  • S. O. Oiwoh Department of Internal Medicine, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
  • O. O. Afolayan Department of Paediatrics, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
  • A. A. Oladeji Department of Radio-Oncology, University of Ibadan and University College Hospital, Ibadan, Oyo State,Nigeria.

Keywords:

Hyperimmunoglobulin E, infection, carcinoma, Immunodeficiency

Abstract

Hyperimmunoglobulin E syndrome is a Primary Immuno-deficiency Syndrome (PIDS) characterized by high serum immunoglobulin E, eczema rash and recurrent sinopulmonary and skin infections. In this report, we present a case of squamous cell carcinoma of the lower lip in a young patient with Hyper IgE syndrome. The patient had initially developed a chronic non-healing ulcer and a biopsy done revealed a squamous cell carcinoma. Immunodeficiency has been recognized as an essential risk factor for cancer through immune dysregulation and defective immunosurveillance.

Published

2021-02-26

Issue

Vol. 38 No. 2 (2021): The West African Journal of Medicine

Section

Case Report
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