ORIGINAL: The Iron Status of Children with and without Sickle Cell Disease at the University of Ilorin Teaching Hospital, Nigeria

West Afr J Med. 2023 October; 40 (10): 1013-1020 PMID: 37905967

Authors

  • M. A. Akintola Department of Paediatrics, University of Osun Teaching Hospital, Osogbo, Osun State, Nigeria.
  • R. M. Ibraheem Department of Paediatrics & Child Health, University 3 of Ilorin and University of Ilorin Teaching Hospital, PMB 1515, Ilorin, Kwara State, Nigeria.
  • S. A. Biliaminu Department of Chemical Pathology and Immunology, University of Ilorin and University of Ilorin Teaching Hospital, PMB 1515, Ilorin, Kwara State, Nigeria
  • S. K. Ernest Department of Paediatrics & Child Health, University 3 of Ilorin and University of Ilorin Teaching Hospital, PMB 1515, Ilorin, Kwara State, Nigeria.
  • A. Ojuawo Department of Paediatrics & Child Health, University 3 of Ilorin and University of Ilorin Teaching Hospital, PMB 1515, Ilorin, Kwara State, Nigeria.

Keywords:

sickle cell disease, iron status, serum ferritin, children

Abstract

Background: Children with sickle cell disease (SCD) are at potential risk of iron overload from chronic transfusion and probable iron deficiency due to accelerated growth. However, only few studies on the iron status of children with SCD in Nigeria are available.

Methodology: A cross-sectional study compared the iron status of 109 children with sickle cell disease with 109 age and sex-matched haemoglobin AA controls at the University of Ilorin Teaching Hospital. Parameters assayed were serum iron, ferritin, transferrin, and haemoglobin (Hb) concentrations. Considering the appropriate reference values for age and sex, these parameters were used to classify the children into high, normal, or low iron status.

Results: The median (interquartile range) serum ferritin level of 180.00 (237.50)ng/ml for the SCD subjects was significantly higher than 70.00 (120.00)ng/ml observed among controls, but the mean Hb and median serum transferrin levels were significantly lower in the subjects compared with the corresponding values in the controls, each showing statistical significance (p<0.05). The median serum iron levels did not differ significantly between the SCD (112µg/dl) and non-SCD (128µg/dl), p=0.309. A high proportion of subjects had low HB status (96.3%) compared with controls (56.9%), p=0.001. A significantly higher proportion of subjects (78%) had high ferritin status compared with the controls (48.3%; p <0.001). Ten (9.1%) SCD children had low serum iron status compared to 28 (25.7%) HbAA controls, p=0.002. Thirty-four (31.2) subjects had low transferrin status which was significantly higher than the corresponding number of controls (8;7.3%; p<0.001).

Conclusion: The children with SCD in the index study were iron-sufficient.

Keywords: Children; Iron status; Serum ferritin; Sickle cell disease.

Published

2023-10-31

Issue

Vol. 40 No. 10 (2023): The West African Journal of Medicine

Section

Articles
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