ORIGINAL: Left Ventricular Function and Geometry of Children with Chronic Kidney Disease (CKD) in a Resource-Poor Setting of Africa
West Afr J Med . 2022 Oct 20;39(10):1095-1103.
Keywords:
Children; Chronic kidney disease; Left ventricular function; Left ventricular geometry.Abstract
Background: Chronic Kidney Disease (CKD) is a multisystemic clinical condition characterized by an irreversible deterioration of renal function that invariably progresses to end-stage renal disease (ESRD). Cardiovascular affectation portends morbidity and mortality in chronic kidney disease.
Objective: The aim of the study was to compare the prevalence of changes in function, and geometry of the left ventricle in children with CKD and their controls.
Methodology: This was a descriptive cross-sectional study. Children aged 6 to 17 years with features suggestive of CKD along with age and sex-matched apparently healthy controls seen at the University of Nigeria Teaching Hospital, Enugu were enrolled consecutively. Blood samples werecollected for baseline investigations and e-GFR, followed by trans-thoracic two-dimensional echocardiography to assess the left ventricular function and geometry. Data was analysed using the statistical package for social sciences (SPSS) version 17.0. Simple frequencies and proportions, Student's t-test and chi-square were applied appropriately. P value at <0.05 was significant.
Results: Out of 9,419 children aged 6-17 years seen within the study period in the hospital, 24 met the criteria for CKD. The incidence rate was 5 cases per million child population per year. Mean age was 12.33 ± 4.24 years, with a male to female ratio of 2:1. Left ventricular hypertrophy (LVH), eccentric LVH and Left ventricular dilatation (LVD) were seen in 50.0%, 33.3% and 41.7% of subjects respectively. Left ventricular diastolic dysfunction and left ventricular systolic dysfunction occurred in 37.5% and 8.3% subjects, respectively.
Conclusion: Prevalence of left ventricular geometry and function abnormalities was high in subjects. Intervention measures are advocated.
Keywords: Children; Chronic kidney disease; Left ventricular function; Left ventricular geometry.
