ORIGINAL: Impact of Parity on Cardiac Structure and Function in Apparently Healthy Pregnant Nigerian Women

West Afr J Med . 2022 Oct 20;39(10):1057-1061

Abstract

Background: There are few and conflicting reports in the literature about the relationship between parity and maternal cardiac function. The study aimed to assess the impact of parity on cardiac structure and function in apparently healthy pregnant women in Nigeria.

Methods: This was a cross-sectional study carried out in 3 tertiary centers in Kano, and 1 in Ile-Ife, Nigeria. 112 apparently healthy pregnant women were consecutively recruited between the 28th and 38th weeks of gestation, and their cardiac structure and function assessed using echocardiography. Left ventricular (LV) systolic dysfunction was defined as LV ejection fraction of below 50%, and diastolic dysfunction was graded using mitral filling and tissue Doppler velocities.

Results: LV systolic dysfunction and diastolic dysfunction were found in 6 (5.4%) subjects and 20 (17.9%) subjects, respectively. Age (p= <0.0001), left atrial (LA) size (P<0.0001), interventricular septal thickness at end diastole (IVSD) (p= 0.005), posterior wall thickness at end diastole (PWTD) (p=0.004) and QRS duration (p= <0.0001) all increased progressively with higher parity, while tricuspid annular systolic excursion (p=0.320) decreased with higher parity. There was significant positive correlation between parity and age (r= 0.475, p= <0.0001), LA size (r=0.332, p= <0.0001), IVSD (r=0.264, p= 0.005) and PWTD (r= 0.343, p= <0.0001). LV systolic function was not significantly associated with parity.

Conclusion: Our findings suggested that parity was significantly associated with myocardial remodeling in apparently healthy pregnant women.

Keywords: Cardiac structure; Parity; Peace registry; Pregnancy.

H Saidu ^1 2, I Y Mohammed ^1 3, N A Ishaq ³, S A Balarabe ⁴, J Tukur ^1 3, T A Adedeji ⁵, O N Makinde ⁶, R A Adebayo ⁷, H Umar ⁸, S A Isezuo ⁸, K M Karaye ^1 3 9