ORIGINAL: Comparison of the Diagnostic Relevance of Albumin Creatinine Ratio Versus Cystatin C in Assessment of Cardiovascular Complication in Type 2 Diabetics

West Afr J Med. 2021 April; 38(4): 328-334 PMID: 33900714

Authors

  • B. K. Myke-Mbata Department of Chemical Pathology, Benue State University, Makurdi, Benue State, Nigeria.
  • S. C. Meludu Department of Chemical Pathology, Nnamdi Azikiwe University, Awka, Anambra State.
  • D. O. Ochalefu Department of Medical Biochemistry, Benue State University, Makurdi, Benue State, Nigeria.
  • B. C. Basil Department of Chemical Pathology, Benue State University, Makurdi, Benue State, Nigeria.

Keywords:

Cystatin-C, Albumin-creatinine ratio, Diabetes mellitus, Cardiovascular Diseases

Abstract

Background: In a bid to reduce cardiovascular complication(s), surrogate markers such asAlbumin-creatinine ratio and Cystatin C (Cys-C) are being evaluated in order to enhance early management of cardiovascular complications of diabetes mellitus.

Aim: Evaluation of the diagnostic relevance of Cystatin- C versusAlbumin-creatinine ratio in assessment of cardiovascular complications (CVC).

Methods: One hundred and two type 2 diabetic patients and 100 control subjects of same age range were recruited for this study. These were further classified according to cardiovascular complications. Cystatin-C, Microalbuminuria, serum creatinine, HBA1c and HBA1c were analysed with standard methods.

Results: The mean concentrations of Cys-C, Microalbuminuria and Albumin-creatinine ratio showed significant increase (p<0.05) in those with cardiovascular complication compared to those without cardiovascular complication. The ROC (receiver operator curve) showed thatAlbumin-creatinine ratio (ACR) had significant sensitivity to cardiovascular complication while Cystatin-C showed no significant sensitivity to cardiovascular complications. Logistic binary regression shows a significant association of ACR with cardiovascular complications unlike Cys-C which showed no significant association (p<0.05).

Conclusion: Cys-C and Albumin-Creatinine ratio increased in diabetics and further deranges with cardiovascular complications. However, Albumin-creatinine ratio showed more diagnostic sensitivity to cardiovascular complications compared to cystatin-C.

Published

2021-04-23

Issue

Vol. 38 No. 4 (2021): The West African Journal of Medicine

Section

Articles
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