CASE REPORT: Rosai-Dorfman Disease in Cervical Lymph Nodes: The Challenges of Diagnosis in a Resource Limited Setting and Use of Immunohistochemistry in the Diagnosis

West Afr J Med. 2021 Mar 22; 38(3):282-286. PMID: 33766573

Authors

  • G. O. Ogun Department of Pathology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Oyo State, Nigeria.
  • B. L. Awosusi Department of Pathology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Oyo State, Nigeria.
  • A. A. Oladeji Radiation Oncology, College of Medicine, University of Ibadan/ University College Hospital, Ibadan, Oyo State, Nigeria.

Keywords:

Rosai-Dorfman disease, Immunohistochemistry, Cervical lymph nodes, Chemotherapy, misdiagnosis

Abstract

We report a case of Rosai-Dorfman disease in a 28-year-old Nigerian woman with a 7-year history of painless prominent bilateral neck swelling which waxed and waned over the years. She had two misdiagnosis hence appropriate therapy was not initiated over the years. She was eventually referred for independent opinion and was diagnosed correctly with review of the histology sections and with the use of CD45, S100, CD 68, CD 15, CD 20, synaptophysin and AE1/AE3 immunohistochemistry markers. Classic features on Haematoxylin and eosin stained sections and positivity of the lesional cells for S100 and CD68 were diagnostic of Rosai-Dorfman disease. She was subsequently placed on oral steroids with minimal objective reduction in the neck circumference from 57 to 46 cm. After two months, she was managed with three courses of chemotherapy (cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone) which resulted to a significant sustained reduction in her neck circumference to 36 cm. She has been on follow up for about a year without a recurrence.

Published

2021-03-22

Issue

Vol. 38 No. 3 (2021): The West African Journal of Medicine

Section

Case Report
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